mutent jean causes migraine

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mutent jean causes migraine

Post by cymbalta on Thu Sep 30, 2010 11:49 pm

Mutant gene causes migraine
The discovery of a faulty gene responsible for migraine - an extremely
painful condition - offers a ray of hope to millions of sufferers.
The finding potentially opens the way to a new class of migraine-busting
drugs and shows how debilitating headaches can be passed from parent to
child.
Researchers from the Medical Research Council Functional Genomics Unit at
the University of Oxford found the gene, called TRESK, in families of
sufferers.
When the gene is mutated, it can more easily trigger the brain's pain
centres and cause severe headaches, reports the journal Nature Genetics.
Around one in four women and one in 12 men experience migraine, triggered by
alcohol, stress, fluorescent lighting and foods such as chocolate, red wine
and caffeine, according to the Daily Mail.
The World Health Organisation rates migraines as a major cause of disability
worldwide and it has been estimated to be the most costly neurological
disorder
in Europe.
Study leader Zameel Cader from Oxford said: "We have now made a major step
forward in our understanding of why people suffer with migraine and how in
certain
cases, your family can literally give you a headache."
During the headache stage, victims experience a pulsating, throbbing pain -
often on one side of head, sensitivity to bright lights and sound, nausea
and
often a strong desire to lie down in a darkened room. Severe attacks can
last for days.
One in every two migraine sufferers believes that changes in the weather can
trigger an attack.
Last year, a study at the Harvard University showed that a drop in
atmospheric pressure and a rise in temperature are triggers.
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Kids with lung disease prone to serious infections at day care
Premature babies at a Neo-natal intensive care unit. File Photo
Premature babies at a Neo-natal intensive care unit. File Photo

A new study has revealed that exposure to common viruses in day-care puts
children with a chronic lung condition caused by premature birth at risk for
serious
respiratory infections.
Johns Hopkins Children's Centre researchers say their findings should prompt
paediatricians to monitor their prematurely born patients, regardless of
age,
for signs of lung disease and to discuss the risks of day-care-acquired
infections with the children's parents. These risks, the researchers found,
include
increased emergency room visits and medication use and more days with
breathing problems.
"Day-care can be a breeding ground for viruses and puts these already
vulnerable children at risk for prolonged illness and serious complications
from infections
that are typically mild and short-lived in children with healthy lungs,"
said lead investigator Sharon McGrath-Morrow, M.D., M.B.A., a lung
specialist
at Hopkins Children's.
Investigators interviewed the parents of 111 children ages 3 and under with
chronic lung disease of prematurity (CLDP) about their child's day-care
attendance,
infections, symptoms, emergency room visits, hospitalizations and use of
medications.
Among the 22 children with CLDP who attended day-care, 37 percent went to
the ER for worsening symptoms since their last day in day-care, compared to
12
percent of children who did not attend day-care. More than 15 percent of
those who attended day-care were hospitalized for viral illness, compared to
6
percent among those who didn't attend day-care. Thirty-nine percent of those
in day-care needed corticosteroids for their illness and 50 percent of them
required antibiotics, compared to 19 percent and 26 percent, respectively,
for those who were not in day-care. Children in day-care had more
respiratory
episodes in the week before their visit to the doctor. More than half of the
children in day-care had respiratory symptoms in the week before their
visit,
compared to 29 percent of those not enrolled in day-care.
CLDP develops in about a quarter of babies born at or before 26 weeks of
gestation, according to the investigators, but even those born as late as 32
weeks
of gestation can develop the condition, the researchers say.
The study has been published in the October issue of Pediatrics.
--------
Acupuncture not effective for stroke recovery: study
A patient undergoing Acupuncture treatment for acute back pain. File Photo
A patient undergoing Acupuncture treatment for acute back pain. File Photo
Acupuncture, the ancient Chinese therapy which is often used to help stroke
victims, does not appear to aid the patient's recovery, a new study has
claimed.
British and South Korean researchers who carried out a systematic review of
several studied on the age-old Chinese pain therapy doesn't actually help
stroke
rehabilitation.
The researchers, who reported their findings in the Canadian Medical
Association Journal (CMAJ), said their study was to gather evidence of the
needle-inserting
method's effectiveness from rigorous randomised clinical trials to recommend
its routine therapeutic use.
For their study, the team led by Dr Edzard Ernst of UK's Peninsula Medical
School reviewed 10 studies (out of a potential 664) to look at a total of
711
patients who had had strokes.
The wrote: "Few randomised, sham-controlled trials have tested the
effectiveness of acupuncture during stroke rehabilitation.
"The majority of the existing studies do not suggest that acupuncture is
effective."
They noted that the only two studies showing positive effect were highly
biased and had poor reporting which made them less reliable that the others
included.
The authors concluded that "the evidence from rigorous studies testing the
effectiveness of acupuncture during stroke rehabilitation is negative."
In a related commentary, Dr Hongmei Wu of West China Hospital, Sichuan
University in Chengdu, said: "The negative effects of true acupuncture for
stroke
recovery based on the systematic review of sham-controlled trials should be
interpreted cautiously."
She cautioned that the study included several weaknesses, such as many of
the included studies had small samples sizes and that the quality of
acupuncture
which varied in the papers is related to effectiveness.
She called for large, rigorous, well-designed trials to better understand
the effects of acupuncture and stroke recovery.
----------
Vitamin supplements 'up skin cancer risk'
A patient who was diagnosed suffering from rare form of skin cancer. File

A patient who was diagnosed suffering from rare form of skin cancer. File
Photo
Scientists have revealed that millions of people who take daily vitamin
pills could be putting themselves at risk of the deadliest form of skin
cancer.
Research has revealed that supplements containing antioxidants and minerals
appear to increase the chances of developing a malignant melanoma.
Volunteers given pills containing vitamin E, ascorbic acid, beta-carotene,
selenium and zinc were four times more likely to get cancer than those who
took
dummy pills.
The findings come from a follow-up study to one in 2007, which revealed the
risks to vitamin-pill poppers. The results of that research, by French
scientists,
showed that out of 13,000 adults, those who took daily supplements to stay
healthy were at much higher risk of skin cancer. To double-check their
findings,
the same team monitored patients for several more years. These results
confirm that the increased risk virtually disappeared once patients stopped
daily
supplements.
Now scientists behind the research, carried out at the National Centre for
Rare Skin Diseases in Bordeaux, are calling for those most at risk of skin
cancer
- fair-skinned types or those with a history of excessive sun exposure -- to
steer clear of supplements.
Women may be more at risk than men, possibly because they have more fat
around the skin, where antioxidants and vitamins are mainly stored.
So far, the only proven way of reducing risk is to use high-protection
creams and wearing suitable clothing.
But it had been widely assumed that taking antioxidants would reduce the
risk, since supplements theoretically protect the skin against damage from
the
sun's rays. The latest study, however, suggests supplements have the
opposite effect.
Scientists do not think taking vitamins actually causes malignant melanoma,
rather it somehow speeds up the development of a tumour, reports the Daily
Mail.
The result has been published in the latest European Journal of Cancer
Prevention.

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